Diabetes mellitus type 1 pathogenesis

diabetes mellitus type 1 pathogenesis differential diagnosis for type 2 diabetes

The authors summarise those genetic, immunological, epidemiological data and those virological studies which suggest connection between insulin-dependent diabetes mellitus and certain types of viruses. There are two basic ways of beta cell destruction caused by different viruses.

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They can destroy beta cells by direct cytolysis or can trigger autoimmune activity. The process is dependent on the genetic make-up of both, the virus and the host. Currently the best understood mechanism involves the Coxsackie B4 virus P2-C protein and a protein on pancreatic beta cell membrane.

Pathophysiology of Diabetes Mellitus

They have similar sequences leading to cross-reactivity and autoimmune response that finally destroys the beta cells. Ezek pl.

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Bonifacio, E. Boitard, C: The differentiation of the immune system towards anti-islet autoimmunity. Clinical prospects.

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Diabetologia Nature,diabetes mellitus type 1 pathogenesis Tempus ITC, Budapest, Ann Rev Immunol 9: J Clin Invest J Trop Pediatr.

Sci USA USA Oldstone, MBA, von Herrath, MG: Virus-induced autoimmune disease: transgenic approach to mimic insulindependent diabetes mellitus and other autoimmune diseases. APMIS, Diabetes Yoon, JW: Induction and prevention of type 1 diabetes mellitus by viruses.

diabetes mellitus type 1 pathogenesis hányás kezelésére cukorbetegség

Diabete Metab Virus Res Diabetes, Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin and interleukin J Virol ,