Diabetes mellitus type 1 pathogenesis

The authors summarise those genetic, immunological, epidemiological data and those virological studies which suggest connection between insulin-dependent diabetes mellitus and certain types of viruses. There are two basic ways of beta cell destruction caused by different viruses.

They can destroy beta cells by direct cytolysis or can trigger autoimmune activity. The process is dependent on the genetic make-up of both, the virus and the host. Currently the best understood mechanism involves the Coxsackie B4 virus P2-C protein and a protein on pancreatic beta cell membrane.

Pathophysiology of Diabetes Mellitus

They have similar sequences leading to cross-reactivity and autoimmune response that finally destroys the beta cells. Ezek pl.

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